June 4
"Reactive Oxygen Species and Matrix Metalloproteinases in Cardiovascular Disease"

Timothy O'Toole, Ph.D.
Assistant Professor of Medicine
Division of Cardiovascular Medicine
University of Louisville

Learning Objectives:
1) To understand the impact that pollutant exposure has on cardiovascular physiology;
2) To understand the role of reactive oxygen species in regulating matrix metalloproteinases in advanced atherosclerotic lesions;
3) To gain an understanding of what microRNAs are and how they contribute to cardiovascular physiology.


June 11
"Oxidized Lipids and Atherosclerosis"

Sanjay Srivastava, Ph.D.
Associate Professor of Medicine
Division of Cardiovascular Medicine
University of Louisville


June 18
"Air Pollution, Environmental Tobacco Smoke and Endothelial Dysfunction: A Common Mechanism of Increased Cardiovascular Disease Risk"

Daniel Conklin, Ph.D.
Assistant Professor of Medicine
Division of Cardiovascular Medicine
University of Louisville
Louisville, Kentucky

Learning Objectives:
1) Review epidemiological associations between air pollution, environmental tobacco smoke (ETS) and increased cardiovascular risk;
2) Describe the potential mechanisms by which air pollution and ETS exposures mediate endothelial dysfunction;
3) Discuss ongoing studies implicating glutathione S-transferase P as a determinant of cardiovascular system sensitivity to air pollution and ETS exposure.


June 25
"Homocysteine to Hydrogen Sulfide (H2S) and Translational Multidisciplinary Approach"

Suresh C. Tyagi, M. Phil., Ph.D., FAHA, FAPS
Professor & Vice Chair for Research
Department of Physiology & Biophysics
Stodghill Endowed Chair in Biomedical Sciences
University of Louisville School of Medicine

Learning Objectives:
Will discuss:
1) Although high dose of hydrogen sulfide may be detrimental the normal dose (nanomolar range) can be beneficial and cardioprotective;
2) Cystathionine gamma lyse (CGL) gene therapy can useful in many diseases such as chronic heart failure, chronic renal failure and cerebral vascular dementias, stroke and Alzheimer's disease;
3) High homocysteine causes many systemic vascular diseases leading to renal and chronic heart failure.


Acknowledgments:
None

Speaker Disclosures:
None

Time & Location
Unless otherwise noted, Division of Cardiovascular Medicine Grand Rounds are held from 8:00 AM - 9:00 AM at the Jewish Hospital Rudd Heart and Lung Center (Top Floor), 201 Abraham Flexner Way, Louisville, KY

Additional Information
For more information, please call Constance Foss at 502-852-1835.

Target Audience
Cardiologists, Cardiac Surgeons, Internists, Family Practitioners, Basic Scientists & other Physicians/Hospital Staff interested in topic(s).

Designation Statement
The University of Louisville Continuing Health Sciences Education office designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Accreditation
The University of Louisville School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.