This multidisciplinary symposium will allow participants to gain greater insight into the latest advances in breast cancer research and treatment, particularly in the area of locally advanced and metastatic cancer. Basic scientists and clinicians involved in all aspects of breast cancer care will have an opportunity to interact and gain a greater mutual understanding resulting in improved care for patients.

Physician discipline(s) and other healthcare professionals for which the course is designed: Surgery, Medical Oncology, Radiation Oncology, Radiology, Pathology, Plastic Surgery, Family Practice, Behavioral Oncology, Internal Medicine, Gynecology, & Advocates.


Learning Objectives & Outcomes
Objective: To understand recent advances in basic, translational and clinical breast cancer research
Outcome: These new advances may be incorporated into clinical practice

Objective: To discuss options to evaluate for metastatic disease
Outcome: Cost-effective options may be chosen for our patients

Objective: To understand the role of surgery in primary tumor extirpation and/or resection of metastatic disease in patients with metastatic patients
Outcome: These recommendations may be incorporated into clinical practice

Objective: To understand current controversies regarding post-mastectomy patients
Outcome: Appropriate recommendations may be made to our patients

Objective: To understand current controversies regarding type and timing of reconstruction, particularly in women with locally advanced breast cancer
Outcome: Appropriate recommendations may be made to our patients

Objective: To discuss advances in the adjuvant and neoadjuvant treatment of patients with locally advanced breast cancer
Outcome: Appropriate recommendations may be made to our patients

Objective: To understand the relevance of circulating tumor cells in clinical practice
Outcome: Tests for CTCs may be appropriately ordered and interpreted

Objective: To understand quality of life issues in metastatic breast cancer patients
Outcome: Appropriate treatment recommendations to improve quality of life may be made to our patients with metastatic breast cancer

Objective: To understand multidisciplinary issues surrounding the care of patients with locally advanced or metastatic breast cancer
Outcome: Appropriate recommendations may be made to our patients


Agenda
7:00 am
Poster/Exhibitor Set-Up

7:30 am
Registration, Continental Breakfast, Poster and Exhibit Viewing

8:00 am
Welcome
Anees B. Chagpar, M.D.

8:15 am
Multidisciplinary Tumor Board Case Discussions
All Faculty

8:45 am
Surgery: Is It Indicated In Metastatic Disease?
Seema Khan, M.D.

9:15 am
Radiation Therapy: Controversies in PMRT
Suresh Dutta, M.D.

9:45 am
Break; Poster and Exhibit Viewing

10:15 am
Plastic Surgery: Controversies In Type & Timing of Reconstruction
Bradon J. Wilhelmi, M.D.

10:45 am
Advances In Systemic Chemotherapy For Locally Advanced & Inflammatory Breast Cancer
Shaheenah Dawood, M.D.

11:15 am
Circulating Tumor Cells: What Do They Mean?
Alvin Martin, M.D., Ph.D.

11:45 am
Lunch; Poster and Exhibit Viewing

12:30 pm
Imaging: Cost-Effective Means of Determining Metastasis
Dennis Holmes, M.D.

1:00 pm
Quality Of Life Issues In Metastatic Breast Cancer Patients
Sheron R. Williams, M.D.

1:30 pm
Oral Scientific Session
Moderator: Anees B. Chagpar, M.D.

2:00 pm
Evaluation/ Adjournment


Faculty
Anees B. Chagpar, M.D.
Course Director
Assistant Professor of Surgery
Division of Surgical Oncology
Director, James Graham Brown Cancer Center Multidisciplinary Breast Clinic
Louisville, KY

Shaheenah Dawood, M.D.
Medical Oncology
MD Anderson Cancer Center
Harvard School of Public Health
Assistant Editor, New England Journal of Medicine

Suresh Dutta, M.D.
KYANA Cancer Institute
Louisville, KY

Dennis Holmes, M.D.
Breast Cancer Specialist and Surgeon
Harold E. & Henrietta C. Lee Breast Center
USC Norris Comprehensive Cancer Center and Hospital
Los Angeles, CA

Seema Khan, M.D.
Professor of Surgery
Director, Bluhm Family Program for Breast Cancer Early Detection and Prevention
Feinberg School of Medicine of Northwestern University

Alvin Martin, M.D., Ph.D.
Professor of Pathology
University of Louisville
Louisville, KY

Bradon J. Wilhelmi, M.D.
Professor
Director of Plastic Surgery
University of Louisville
Louisville, KY

Sheron R. Williams, M.D.
Medical Director, Survivorship Program
Norton Healthcare
Louisville, KY


Continuing Education Credit
Physician Credit - The University of Louisville Continuing Health Sciences Education office designates this educational activity for a maximum of 4.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Nursing Credit - This program has been approved by the Kentucky Board of Nursing for 5.4 contact hours through the University of Louisville School of Nursing, provider Number 3-0046-12-07-142, expiration date Dec. 1, 2007. The Kentucky Board of Nursing approval of an individual nursing education provider does not constitute endorsement of program content. Participants must attend entire session, provide license and social security number, and complete evaluation to receive contact hours.


Registration
Online and telephone registration for this conference is now closed - you may still attend by registering and paying at the registration desk on the morning of the program. Registration begins at 7:30 a.m.


Cancellation Policy:
Cancellations e-mailed to chse@louisville.edu on or before 8/24/07 will receive a full refund minus a $15 processing fee. There will be no refund for cancellations received after 8/24/07.


Hotel Info & Directions
The program will be held at the Louisville Marriott Downtown, located at 280 West Jefferson Street.

Driving Directions:
From Louisville Intl. Airport (Standiford Field):
Take I-65 North toward Indianapolis
Take the Brook Street exit - go straight
Turn left onto Muhammad Ali Blvd
Turn right onto S. Second Street
Turn left onto W. Jefferson Street
Marriott hotel is at 280 W Jefferson St

For more details, go to http://www.mapquest.com


Background/Needs Assessment
Breast cancer is the leading malignancy affecting women in the United States, with over 178,000 women being diagnosed each year. The management of patients with breast cancer is becoming increasingly complex, with multiple disciplines being involved in the patient's care. The need for communication between the disciplines and a broad understanding of multidisciplinary considerations is critical to optimize the management of breast cancer patients.

In addition, as advances in every field of breast cancer management are emerging at a rapid pace, it is imperative that practitioners stay current in their understanding of state-of-the-art care for their breast cancer patients. Controversies continue to exist regarding optimal care of breast cancer patients, especially in the current era of rapidly developing knowledge, and forums for open debate of these issues are needed.

Finally, the explosion of knowledge and information regarding the biology of breast cancer at the molecular level is significantly impacting the clinical management of patients, and there are issues in clinical practice that warrant investigation in the laboratory. The interaction between scientists and clinicians in a productive symposium allows not only for the development of fruitful collaborations but also the development of a broader understanding of breast cancer, from the bench to the bedside.

The purpose of the Louisville Breast Cancer Update is therefore to contribute to improved cancer discovery, detection and management through dissemination of knowledge and collaboration between scientists and clinicians. This is, to our knowledge, the only symposium of its kind in Kentucky.

The Louisville Breast Cancer Update began in 2004 as a regional meeting to disseminate and exchange knowledge regarding advances in the multidisciplinary management of breast cancer. The meeting has continued over the past three years, with attendance averaging ~150 people per year. All aspects of the multidisciplinary management of breast cancer care are covered including imaging, surgical oncology, reconstruction, pathology, systemic chemotherapy, hormonal therapy, radiation oncology, and supportive care.

We have attracted nationally-renowned speakers including Gabriel Hortobagyi, David Page, Terry Mamounas, Frank Vicini, Kelly McMasters, Pat Whitworth, Vincente Valero, Charles Vogel, Banu Arun, Mitch Schnall, Elizabeth Rafferty and others. Last year, a poster session was added to allow participants to learn more about discoveries in breast cancer research, and to facilitate collaborations between researchers and clinicians. The meeting has been very well received, and evaluations from previous years have been very positive, with 98% of participants either agreeing or strongly agreeing that this should be an annual symposium.

Based on the evaluations of the previous years' symposia, there is a need to continue this annual symposium which has become an important source of information and education for health care providers caring for patients with breast cancer. The meeting continues to grow and gain recognition; last year, we were awarded a five-year R13 grant from the National Cancer Institute in support of this worthwhile educational event. However, this grant only provides partial support for this event, and sponsorship from community foundations and industry is critical.


Special Services
If you need special accommodations due to a disability, or for an alternative form of course materials, please contact us at chse@louisville.edu. Continuing Health Sciences Education fully complies with the legal requirements of the ADA and the rules and regulations thereof.


Accreditation
The University of Louisville School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.